上海工程技术大学孙智华教授课题组拟招收2名硕士研究生（需要考数学）{"考研派考研调剂中心" 小程序小编整理}。欢迎大家报名。 主要从事有机小分子催化的不对称合成，过渡金属催化的方法学研究，生物活性分子化合物库的构建及其天然产物的全合成研究，药物合成工艺研究。目前主要研究新的氮杂卡宾，异硫脲类体系等有机小分子催化剂，并运用其催化不同类型的反应，以及含硼，硫，氟化合物的合成方法学研究，用于药物筛选。 该组已毕业28个研究生，毕业后主要分成二个去向{"考研派考研调剂中心" 小程序小编整理}：第一，国内外高校继续博士阶段受训；第二，国内企业从事药物合成研发。 调剂要求：必须报考工科专业，考试科目必须是英语一，数学二，必须达到国家一区分数线，英语过六级优先，认真踏实、责任心强。 研究兴趣： 1）有机合成：a天然活性产物的全合成。 b不对称合成。 c过渡金属催化的偶联的方法学。 d药物合成工艺。 2）药物化学及设计：a基于蛋白晶体结构的活性化合物的设计。 b研究范围在肿瘤，抗病毒（乙肝，丙肝，艾滋病等），二型糖尿病。 最近发表的研究工作： 1）XiaofangLei,YuanyuanWang,ErkangFan,andZhihuaSun*,InSituActivationofDisulfidesforMulticomponentReactionswithIsocyanidesandaBroadRangeofNucleophiles,OrganicLetters,2019,21,?1484-1487. 2）ShengfengWu,XiaofangLei,ErkangFan,andZhihuaSun*,Thermolysis-InducedTwo-orMulticomponentTandemReactionsInvolvingIsocyanidesandSulfenic-Acid-GeneratingSulfoxides:AccesstoDiverseSulfur-ContainingFunctionalScaffolds,OrganicLetters,2018,20,?522-525. 3）FanghuiXu,YuanChen,ErkangFan,andZhihuaSun*,Synthesisof3-SubstitutedAryl[4,5]isothiazolesThroughanAllHeteroatomWittig-EquivalentProcess,OrganicLetters,2016,18,?2777-2779. 4）HaochenXuandZhihuaSun*,GeneralCycloadditionbetweenaTrimethylsilyl-CappedAlkyneandanAzideCatalyzedbyanN-HeterocyclicCarbene-CopperComplexandPyridine-Biscarboxamide,AdvancedSynthesisCatalysis.2016,358,1736-1740. 5）TaoLiu,Ling-yanChenandZhihuaSun*,AsymmetricReductionoftert-ButanesulfinylKetiminesbyN-HeterocyclicCarbeneBoranes,TheJournalofOrganicChemistry,2015,80,11441-11446. 6）JuhongWeiandZhihuaSun*,tert-ButylSulfoxideasaStartingPointfortheSynthesisofSulfinylContainingCompounds,OrganicLetters,2015,17,5396-5399.LiliangHuang,ChengxiangHeandZhihuaSun*,ApplicationofChan-LamcrosscouplingforthesynthesisofN-heterocycliccarbeneprecursorsbearingstrongelectrondonatingorwithdrawinggroups;ScientificReports.2015,5,12432,DOI:10.1038srep12431. 7）HuihuiJia,HuangdiFeng,ZhihuaSun*,MulticomponentDominoReactionsofHydrazinecarbodithioates:AConciseAccessto3-Substituted5-Thiol-1,3,4-Thiadiazolines;OrganicBiomolecularChemistry.2015,13,8177-8181. 8）HuangdiFeng,HuihuiJia,andZhihuaSun*,AMetal-FreeApproachtowardSaturatedN-PropargylHeterocyclesviaAnnulationDecarboxylativeCouplingSequence;AdvancedSynthesisCatalysis.2015,357,2447-2452. 9）HuihuiJia,HuangdiFeng,ZhihuaSun*,Decarboxylativedipropargylationofprimaryamineswithpropiolicacidsandformaldehydeviametal-freecoupling,Tetrahedron.2015,71,2724-2728. 10）YuyuXia,Ling-yanChen,ShangLv,ZhihuaSun*,andBingWang*,Microwave-AssistedorCu-NHC-CatalyzedCycloadditionofAzidoDisubstitutedAlkynes:BifurcationofReactionPathways;TheJournalofOrganicChemistry.2014,79,9818-9825. 11）HuangdiFeng,HuihuiJia,andZhihuaSun*,MildandCatalyst-FreePetasisDecarboxylativeDominoReaction:ChemoselectiveSynthesisofNBenzylPropargylamines;TheJournalofOrganicChemistry.2014,79,11812?11818. 12）LiliangHuang,YongCao,ManpingZhao,ZhongfengTangandZhihuaSun*,Asymmetricborylationof,-unsaturatedesterscatalyzedbynovelringexpandedN-heterocycliccarbenesbasedonchiral3,4-dihydroquinazoliniumcompounds;OrganicBiomolecularChemistry.2014,12,6554-6356. 13）FengGao,HuangdiFengandZhihuaSun*,Pd-NHC-CatalyzedSynthesisofdiarylketones;TetrahedronLetters.2014,55,6451-6454. 14）KunWen,HanWang,JinboChen,HeZhang,XiaodanCui,ChaoWei,ErkangFanandZhihuaSun*,ImprovingCarbene-CopperCatalyzedAsymmetricSynthesisofalpha-AminoboronicEstersUsingBenzimidazole-BasedPrecursors;TheJournalofOrganicChemistry.2013,78,3405-3409. 15）LeWang,YanWang,YueZheng,PinakiS.BhaduryandZhihuaSun*,Regioselectiveformylationof1,3-disubstitutedbenzenethroughinsituLithiation;TetrahedronLetters.2013,54,6053-6056. 16）HanWang,YuyuXia,ShangLv,JingliXuandZhihuaSun*,FacialandPracticalSynthesisofBenzimidazole-BasedN-HeterocyclicCarbenes;TetrahedronLetters.2013,54,2124-2127. 17）KunWen,JinboChen,FengGao,PinakiS.Bhadury,ErkangFanandZhihuaSun*,MetalfreecatalytichydroborationofmultiplebondsinmethanolusingN-heterocycliccarbeneunderopenatmosphere;OrganicBiomolecularChemistry.2013,11,6350-6356. 18）ZhihuaSun*,HanWang,KunWen,YaLiandErkangFan,Solventfreeorlowsolventlargescalepreparationofchloropyrimidineandanalogs;TheJournalofOrganicChemistry.2011,76,4149-4153.